https://www.selleckchem.com/products/arn-509.html
Strikingly, the mutated platelets had a significantly reduced number of dense granules, which could explain impaired ADP secretion upon platelet activation, and a diminished second wave of activation. Together, our study highlights for the first time the influence of a hyperactive JAK2 on platelet activation-induced ADP secretion and dense granule homeostasis, with consequent effects on platelet activation properties. Together, our study highlights for the first time the influence of a hyperactive JAK2 on platelet activation-induced ADP
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