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Cell viability assay showed that the enzyme-digested CCA (CCAD) exhibited significant preventive effects on hydrogen peroxide- and UVA-induced cellular demise. The in vitro scrape assay indicated that CCAD managed to avoid hydrogen peroxide-induced injury repairing delay in HGF cellular sheets. Immunostaining and imaging evaluation revealed that CCAD could suppress UVA-reduced expression of type IV collagen and elastin in both HGF cells as well as the 3D epidermis equivalents. Utilizing