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No differences were found in the content of monoamines. We discovered a synchronous effect on mRNA expression and protein content of 5-HT2a and 5-HT4 receptors in the prefrontal cortex, as well as decreased content of serotonin transporter and increased content of tryptophan hydroxylase in the hypothalamus of irradiated rats. Rolapitant affected the protein amount of a number of serotonin receptors in the amygdala of irradiated rats. Rolapitant may be the first atypical radioprotector, providing symptomatic treatment of CNS functional
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