https://www.selleckchem.com/pr....oducts/Cyclopamine.h
g. PC(160/16, PC(181/20, PC(38, PC(181/221)), ceramides (e.g. Cer(d180/22, Cer(d42, Cer(d181/241)) and hexosylceramides (e.g. HexCer(d181/16, HexCer(d181/22) were higher in Apcfl/fl organoids, whereas levels of sphingomyelins (e.g. SM(d181/14, SM(d181/16) were lower compared with WT. These observations indicate that cellular metabolism of sphingomyelin was up-regulated, resulting in the cellular accumulation of ceramides and production of HexCer due to the absence of Apcfl/fl in the organoids. Our observations demo
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