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ADHD Treatment Medication Treatment for ADHD for adults usually involves medication and psychosocial therapy. Medications used to treat ADHD include stimulants and nonstimulant medications. Stimulants, such as methylphenidate and lisdexamfetamine, act on chemical messengers in the brain to boost mood and concentration, as well as control of impulses. and guanfacine, both of both of which are non-stimulant ADHD drugs, are prescribed to adults, teens or children who are not responsive to stimulants. Stimulants The most commonly used medications to tre