https://www.selleckchem.com/pr....oducts/Bortezomib.ht
using the LSL-Cas9-Tg model, and that phenotypes observed utilizing these models can be confidently interpreted as being gene specific, and not confounded by the chronic overexpression of Cas9. β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the effects of miR-21 on β-cell function using invitro and invivo systems. We developed a tetracycline-on system of pre-miR-21 induction in clonal β-cells and human islets, along with tra
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