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To evaluate the accuracy of methylene blue (M for diagnosing oral cancer and precancer. PubMed, Cochrane Database, Embase, Web of Science, SCOPUS, and Google Scholar. Two authors working independently reviewed 6 databases from their dates of inception until April 2020. Studies exploring oral mucosal disorders as detected by MB were assessed. True-positive, true-negative, false-positive, and false-negative data were extracted for each study. Methodological quality was evaluated with the Quality Assessment of Diagnostic Accuracy Studies