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However, the underlying hepatocyte barrier-protective molecular mechanisms of cholestatic liver damage remain poorly comprehended. Interestingly, present research indicates that sphingosine-1-phosphate (S1P) participated in the entire process of cholestasis by activating its G protein-coupled receptors S1PRs, regaining the stability of hepatocyte tight junctions (TJs). Right here, we revealed that SEW2871, a selective agonist of sphingos