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Background and aims Multiple pharmacologic treatments are available for the management of irritable bowel syndrome (IBS), and a large body of evidence has been presented. However, the strength and credibility of the evidence have not been comprehensively evaluated. We aimed to review the systematic reviews and meta- analyses of pharmacologic treatments for IBS and evaluate the credibility of the findings. Methods We searched MEDLINE, Embase, and Cochrane library from inception to September 2019 for systematic reviews evaluating the eff