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A previous study showed that irrigation with 100 mL saline reduced residual common bile duct (CBD) stones, which potentially cause recurrent stones after endoscopic retrograde cholangiopancreatography. To determine whether saline irrigation can improve CBD clearance after lithotripsy. This prospective self-controlled study enrolled patients receiving mechanical lithotripsy for large ( 1.2 cm) CBD stones. After occlusion cholangiography confirmed CBD stone clearance, peroral cholangioscopy (POC) was performed to determine clearance s