https://www.selleckchem.com/pr....oducts/Camptothecine
Hypothermic circulatory arrest (HCA) is associated with neurologic morbidity, in part mediated by activation of the N-methyl-D-aspartate glutamate receptor causing excitotoxicity and neuronal apoptosis. Using a canine model, we hypothesized that the N-methyl-D-aspartate receptor antagonist MK801 would provide neuroprotection and that MK801 conjugation to dendrimer nanoparticles would improve efficacy. Male hound dogs were placed on cardiopulmonary bypass, cooled to 18°C, and underwent 90min of HCA. Dendrimer conjugates (d-MK801) w
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