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Furthermore, the alterations in GLP-1 secretion had been proved to be needed for the upkeep of normoglycemia in this obesogenic environment. Analysis regarding the main L-cell transcriptome, also associated with intestinal microbiome, additionally demonstrated time-of-day- and diet-dependent modifications paralleling GLP-1 secretion. Finally, researches in antibiotic-induced microbial exhausted and in germ-free mice with and without fec