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ADHD Medication - Stimulants Stimulants alter how the brain releases chemicals that affect concentration. Doctors typically start patients with ADHD with stimulants, and then increase the dose that helps them. Antidepressants are also used by people suffering from ADHD (not just for depression). These medications are based on the same chemicals that stimulants use, but they have fewer side-effects. Stimulants The first medication doctors prescribe for ADHD is stimulants. They help by increa