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Due to recruitment difficulties, the study was terminated prematurely. Symptom severity decreased significantly in both the prednisone and placebo treatment arm (p0.001). The degree of improvement was not significantly different between treatment arms (p=0.96). No serious adverse events occurred during the treatment phase. There is no indication that prednisolone has a beneficial effect on symptom severity, as adjunctive treatment in patients with schizophrenia, as compared to placebo. Adjunctive treatment with prednisolone did not i