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How Does Medication For ADHD Work? Most people find that medication can help ease their symptoms. Finding the right drug in the right dosage takes time, open communication and patience with your GP. Treatments for ADHD work by adjusting the levels of certain chemical messengers in your brain. The stimulant medications, such as methylphenidate, aid in concentration and reduce hyperactivity and impulsivity. Atomoxetine (Strattera) and guanfacine (Te