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Heterogeneous MMR protein staining had been noticed in 12 cases. In microsatellite steady (MSS) instances, TP53 mutation showed up to accompany heterogeneous staining (HS) of MLH1. However, TP53 difference wasn't observed with MSI-H occurrence. Cases showing heterogeneous MSH6 protein staining revealed MSH6 mutations. Some situations with the exact same MMR protein staining set had differing MSI results. Within one instance whoever main and metastatic foci provided MLH1-HS and PMS2-HS, the micro