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Objective to analyze prevalence and factors associated with lifetime drug use in adolescents. Methods this was a cross-sectional study carried out in 2015 with elementary and high school students in Cuiabá, MT, Brazil, aged 10-19; drug use (except alcohol and tobacco) was analyzed according to sociodemographic, school and family variables; data were submitted to descriptive analysis and Poisson regression to estimate prevalence ratios (PR) and 95% confidence intervals (95%CI). Results drug use prevalence was 23.5% (95%CI 20.8;26.4) and
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