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Our approach reveals that caribou conservation in Alberta is leading to a conservation debt on the order of $800 million CAD. This article is protected by copyright. All rights reserved.The features of two iconic chemical classes are united in the structure of the highly complex diterpene canataxpropellane and set a daunting challenge that has been met by the Gaich group. Their daring strategy and its benefit to the field of terpene chemistry is presented and discussed in this Highlight. © 2020 Wiley-VCH Verlag GmbH Co. KGaA, Wei