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These findings could provide the basis for the development of TH inhibitors as context-dependent anti-tumor agents.AIM This 18 month intervention study aims to determine the efficacy of a lifestyle modification program on prediabetes reversal among Saudi adults. METHODS An 18 month randomized, multicenter trial was conducted among Saudis with prediabetes aged 25-60 recruited from King Salman Hospital and primary care centers in Riyadh, Saudi Arabia. A total of 180 consenting individuals were randomized (11) to receive either intensive li