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The aim of this study was to investigate the role of the insulin-like growth factor-1 receptor (IGF-1R) β-catenin signaling axis in bone impairment induced by hyperglycemia in ovariectomized rats. Rats were divided into four groups. The sham group received sham operation and a single intraperitoneal administration of vehicle. The ovariectomy (OVX) group was subjected to bilateral OVX and vehicle injection. The streptozotocin (STZ) group received sham operation and a single STZ injection to induce hyperglycemia. The OVX + STZ group rece