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Our outcomes suggest a model of Leishmania genomic version during sand fly infection, with oxidative DNA damage and DNA repair processes likely driving haplotype and allelic selection. The experimental and computational framework provided right here provides a useful plan to assess evolutionary adaptation of other eukaryotic pathogens of their insect vectors, such as Plasmodium spp, Trypanosoma brucei, and Trypanosoma cruzi.Carbodiimide-fueled anhydride bond formation has been utilized to enhance the mechanical
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