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nificant number of ART cycles and is found to be cost-effective as it avoids incurring the cost of two ART cycles. Ca signaling pathway is suggested to play an essential role in mediating oocyte maturation. The aim of this study was to evaluate intracellular Ca of resistant immature oocytes that failed to resume meiosis following subsequent culture reach metaphase II after calcium ionophore A23187 activation. This analytical experimental study was conducted at Animal Science Laboratory of Indonesian Medical Education and Research Instit