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© 2020 Society of Chemical business. Dietary polyphenols show encouraging results in mechanistic and preclinical scientific studies regarding the regulation of cardiometabolic changes. Nonetheless, medical trials have supplied contradictory results, with high inter-individual variability. This study explores the role of gut microbiota and microRNAs (miRNAs) as factors contributing to the inter-individual variability in polyphenol reaction. 49 topics with at the least two aspects of metabolic syndrome are divided between r