https://www.selleckchem.com/pr....oducts/Bosutinib.htm
05). The presence of BIX02189, a specific inhibitor of MER/ERK, caused a much greater cytotoxicity, i.e., higher cell death, more ROS production, and worsened apoptosis, than did the treatment with Mn alone. Following Mn exposure, the expression of a downstream effector Bcl- 2 was reduced by 48 % while those of Bax and Caspase-3 were increased by 266.7 % and 90.1 %, respectively, as compared to controls (p less then 0.05). Conclusion Taken together, these data provide the initial evidence that the signaling transduction cascade mediat
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