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Finding the Best Medication For ADHD Stimulants are the most frequently prescribed medications for ADHD. They include methylphenidates and amphetamines. Short-acting stimulants are effective in less than an hour and should be taken multiple times throughout the day. Long-acting stimulants last for up to 16 hours and are taken once a day. Your doctor might prescribe antidepressants or other types of medications "off-label", to treat ADHD symptoms. These drugs are approved to treat disorders like depression or anxiety. Stimulants The most f