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To validate a simplified Chinese version of the therapy-related symptom checklist for children (TRSC-C) in children with cancer. Reliability was assessed by internal consistency and test-retest coefficients. Dimensionality and construct validity were clarified using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Pearson's correlation coefficient was calculated between the TRSC-C and the PedsQL 3.0 cancer model (PedsQL 3. and the Lansky Play Performance Scale (LPPS) to test concurrent validity. A Student's t-t