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The purpose of this study was to examine associations between opioid use and the degree of mental health-related disability due to emotional/behavioral problems as measured by the World Health Organization Disability Assessment Schedule (WHODAS) instrument in a national sample of pregnant women. We used data from the National Survey on Drug Use and Health 2014-2017 which included 2,888 pregnant women 18years or older. The WHODAS instrument was utilized to measure disability as the degree of functional impairment due to emotional/behaviora