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The purpose of the present study was to investigate the effect of acupuncture on xerostomia in irradiated patients with head and neck squamous cell carcinoma (HNSCC). A preventive, 2-arm, parallel, single-blind trial was performed. Patients with HNSCC (N=296) were checked for eligibility, and 107 patients were enrolled in the study. The study comprised 1 group that did not receive the intervention (n=55) and the interventional group that received traditional and auricular acupuncture (n=52). The primary outcome was the reduction of the