https://www.selleckchem.com/pr....oducts/selonsertib-g
Objective Anti-citrullinated protein antibodies (ACPA) are a hallmark of seropositive rheumatoid arthritis (RA). Yet, the precise disease-relevant autoantigen(s) targeted remains debated. By utilizing patient-derived monoclonal ACPA, rather than serum-analysis, we could characterize the multi-reactivity to different protein modifications and reveal autoantibody subsets. Methods A head-to-head comparison of 12 CCP2-positive human monoclonal ACPA generated from six RA patients was performed. We used a cDNA-based protein array
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