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001). Tumor mutation profiles stratify patients by risk groups but not by country. Conclusions High-risk patients appear to survive significantly longer (p less then 0.001) if they receive individualized treatments after the exhaustion of standard of care treatments. Secondly, the tumor mutation landscape in Americans and Germans is congruent and thus warrants the transatlantic exchange of successful treatment protocols and the harmonization of guidelines.Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence am