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and knock-out alternations and thereby bring significant treatment outcomes in breast cancer have also been summarized. Since frameless stereotactic radiosurgery (SRS) techniques have been recently introduced, hypofractionated SRS (HF-SRS) for large brain metastases (BMs) is gradually increasing. To verify the efficacy and safety of HF-SRS for large BMs, we aimed to perform a systematic review and compared them with SF-SRS. We systematically searched the studies regarding SF-SRS or HF-SRS for large ( 2cm) BM from databases including