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Although a uniform terminology to classify neuroendocrine neoplasms arising in various systems has recently already been recommended by WHO/IARC, some issues remain unsolved or must be clarified. In this review, we talk about the lights and shadows of the current whom classifications used to determine and define NENs of this pituitary gland, lung, breast and those for the mind and neck area, and digestive and urogenital systems.Although the entire medical resul