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Objective To compare F-shunt and oxygen content indices in sheep ventilated with a positive end-expiratory pressure (PEEP) of 5 cmH2O alone or preceded by a stepwise alveolar recruitment manoeuvre (ARM). Study design Randomized crossover design. Animals A total of six nonpregnant Brogna ewes weighing 34-47 kg, undergoing thoracolumbar magnetic resonance scan. Methods In medetomidine-sedated sheep, anaesthesia was induced with propofol and maintained with isoflurane 1.1% ± 0.1% and an inspired oxygen fraction (FIO2) of 0.4. Animals were pl