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Among various drug delivery systems, core-shell nanoparticles have many advantages. Inspired by nature, biomimetic synthesis has emerged as a new strategy for making core-shell nanoparticles in recent years. Biomimetic mineralization is the process by which living organisms produce minerals based on biomolecule templating that lead to the formation of hierarchically structured organic-inorganic materials. In this minireview, we mainly focus on the synthesis of core-shell nanoparticle drug delivery systems via biomimetic mineralization.