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We detected chronological increases when you look at the hCD2-positive populace in T lymphocytes that occurred in a p16-dependent fashion, which reflected physiological aging. We then confirmed the large sensitiveness of hCD2-SAP to hCD2 and validated its effectiveness to get rid of p16-positive cells, particularly in T lymphocytes. The several administration of hCD2-SAP for a prolonged p16-positive mobile deficiency partially restored aging-related ph