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Consequently, these tumors tend to be heterogenous concerning the site of beginning, practical status, amount of aggression, and prognosis. When managing customers with neuroendocrine tumors, one of the main challenges for doctors is determining the best cyst level and thus classifying patients into risk categories. Through the years, the classification of the tumors changed significantly, usually causing confusion due to medical, molecular, and immunohistochemical variability. This review