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How Does ADHD Medication Work? When one neuron sends signals to another, it uses chemicals known as neurotransmitters. These need to travel through a tiny gap known as a synapse. Some ADHD medications can make the passing along of these messages more effective. They may aid neurons in releasing more neurotransmitters or slow the process of reuptake (called reuptake inhibitors). Doctors begin ADHD patients with a low dose and monitor their reaction. They gradually increase the dosage to f