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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD have a decrease in symptoms when they take medication. Every person's reaction to medication is different, and side effects are sometimes problematic. Methylphenidate belongs to a class of drugs referred to as stimulants. It works by increasing levels of a chemical within the brain that assists in controlling attention and behavior. Stimulant medication Stimulant medications improve concentration and attention for 70% to 80% of children and adults that use it. T