https://www.selleckchem.com/pr....oducts/l-kynurenine.
Antibodies targeting xCT, but not those targeting Her2, directly affected CSC viability, self-renewal and migration, inducing the antimetastatic effect of xCT vaccination. Our findings present a new therapy for Her2+ breast cancer, demonstrating that CSC immunotargeting via anti-xCT vaccination synergizes with Her2-directed immunotherapy.Tumor-associated macrophages (TAM) have important roles in cancer progression, but the signaling behind the formation of protumoral TAM remains understudied. Here, by single-cell RNA sequencing, we
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