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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If a person is suffering from both ADHD and anxiety or depression, addressing the first can usually help the second. Mental health professionals often prescribe antidepressants or stimulants for depression along with an ADHD medication. Wellbutrin (bupropion) and Effexor, (venlafaxine), are the two most common antidepressants prescribed to treat ADHD "off-label". These medications increase the levels of neurotransmitters dopam