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Applying electrical stimulation, Dex release was augmented, with a maximum of ca. 32% after 24 h. The designed FMNPs provide a powerful biomaterial-based technological tool for electro-responsive controlled drug delivery, capable of surpassing the associated lack of efficiency and stability of current carriers.Vinpocetine (VNP), a semisynthetic drug, is utilized for the treatment of cerebrovascular and memory disorders. This work aimed at formulation of biodegradable VNP long-circulating nanoparticles utilizing Polyethylene glycol meth