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The aqueous extract of Launaea arborescens reduced paw volume after 180min and 120min for histamine and serotonin respectively with dose-dependent. Concerning of TRPV1 receptors, the inhibition was showed at doses 100mg and 300mg. Our results contribute towards validation of the traditional use of Launaea arborescens for inflammation ailment. Our results contribute towards validation of the traditional use of Launaea arborescens for inflammation ailment.Respiratory viral infections are major cause of highly mortal pandemics. They are im