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Parkinson's disease is the second most common neurodegenerative disease. The disease is more prevalent in aged individuals compared to young ones. The present study aimed to investigate the factors associated with PD in the population of Khyber Pakhtunkhwa, Pakistan. In this study, the questionnaire was filled from 600 PD patients, which include 54 familial cases, and 1,200 control subjects. To study the risk of PD in familial cases, questionnaires were also filled from the cases and controls. This study revealed that depression symptomol