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The study aimed to determine whether dental pulp stem cell-derived exosomes (DPSC-Exos) exert protective effects against cerebral ischaemia-reperfusion (I/R) injury and explore its underlying mechanism. Exosomes were isolated from the culture medium of human DPSC. Adult male C57BL/6 mice were subjected to 2hours transient middle cerebral artery occlusion (tMCAO) injury followed by 2hours reperfusion, after which singular injection of DPSC-Exos via tail vein was administrated. Brain oedema, cerebral infarction and neurological impairment