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Older age (p=0.001), higher CRP (p=0.038), elevated lactate dehydrogenase (p=0.046) and interferon treatment (p=0.001), but not glycaemic status/HbA1c, independently predicted Nab titres. Rate of Nab titre decline was comparable across glycaemic status. COVID-19 patients with worse glycaemic status were more likely to deteriorate clinically, mediated through the association of worse glycaemic status with older age, more severe inflammation and higher viral loads. Importantly, Nab responses did not differ across glycaemic status. COVID-19