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Quantification and morphological characterization of the microglial and the astrocytic cells of the dentate gyrus 24 months p.i. indicated heightened immune activity after high dose irradiation (0.125 and 0.5 Gy) while conversely, low dose (0.063 Gy) induced more neuroprotective features. This is one of the first studies demonstrating such long-term and late-onset effects on brain and behaviour after a single radiation event in adulthood. This is one of the first studies demonstrating such long-term and late-onset effects on brain and b