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48 ng·mL-1, 0.53 ng·mL-1, 0.50 ng·mL-1, 0.56 ng·mL-1, and 0.38 ng·mL-1, respectively. Five clusters based on clinical characteristics have been suggested as diabetes subtypes one autoimmune and four subtypes of type 2 diabetes. In the current study we replicate and cross-validate these type 2 diabetes clusters in three large cohorts using variables readily measured in the clinic. In three independent cohorts, in total 15,940 individuals were clustered based on age, BMI, HbA , random or fasting C-peptide, and HDL-cholesterol. Clusters were