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As a whole, 35 chemical substances were examined [15 genotoxic hepatocarcinogens (GTHCs), 9 non-genotoxic hepatocarcinogens (NGTHCs), and 11 non-genotoxic non-hepatocarcinogens (NGTNHCs)]. Because of this, 12 marker genetics (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2, and Tubb4b) were suggested to discriminate GTHCs from NGTHCs and NGTNHCs. U.S. Environmental Protection Agency examined DEGs induced by 4 known GTHCs in rat liver utilizing DNA microarray
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