https://www.selleckchem.com/pr....oducts/omaveloxolone
Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied wildtype (WT) and MyD88 Bb-stimulated bone marrow-derived macrophages (BMDMs). MyD88 BMDMs exhibit impaired uptake of spirochetes but comparable maturation of phagosomes following internalization of spirochetes. RNA-sequencing of infected WT and MyD88 BMDMs identified a large cohort o
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