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BACKGROUND Mononuclear cells play key roles in the pathogenesis of HIV associated neurocognitive disorders (HAND). Limited studies have looked at the association of markers of monocyte activation with HAND in Africa. We examined this association among HIV-1 infected patients in Nigeria. METHOD A total of 190 HIV-infected treatment-naïve participants with immune marker data were included in this cross-sectional study. Plasma levels of soluble CD14 (sCD14), soluble CD163, monocyte chemo-attractant protein-1 (MCP-1), tumor necrosis factor-
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